# -------------------------------------------- # CITATION file created with {cffr} R package # See also: https://docs.ropensci.org/cffr/ # -------------------------------------------- cff-version: 1.2.0 message: 'To cite package "hce" in publications use:' type: software license: MIT title: 'hce: Design and Analysis of Hierarchical Composite Endpoints' version: 0.9.3 doi: 10.32614/CRAN.package.hce abstract: 'Simulate and analyze hierarchical composite endpoints. Includes implementation for the kidney hierarchical composite endpoint as defined in Heerspink HL et al (2023) “Development and validation of a new hierarchical composite end point for clinical trials of kidney disease progression” (Journal of the American Society of Nephrology 34 (2): 2025–2038, ). Win odds, also called Wilcoxon-Mann-Whitney or success odds, is the main analysis method. Other win statistics (win probability, win ratio, net benefit) are also implemented in the univariate case, provided there is no censoring. The win probability analysis is based on the Brunner-Munzel test and uses the DeLong-DeLong-Clarke-Pearson variance estimator, as described by Brunner and Konietschke (2025) in “An unbiased rank-based estimator of the Mann–Whitney variance including the case of ties” (Statistical Papers 66 (1): 20, ). Includes implementation of a new Wilson-type, compatible confidence interval for the win odds, as proposed by Schüürhuis, Konietschke, Brunner (2025) in “A new approach to the nonparametric Behrens–Fisher problem with compatible confidence intervals.” (Biometrical Journal 67 (6), ). Stratification and covariate adjustment are performed based on the methodology presented by Koch GG et al. in “Issues for covariance analysis of dichotomous and ordered categorical data from randomized clinical trials and non-parametric strategies for addressing them” (Statistics in Medicine 17 (15-16): 1863–92). For a review, see Gasparyan SB et al (2021) “Adjusted win ratio with stratification: Calculation methods and interpretation” (Statistical Methods in Medical Research 30 (2): 580–611, ).' authors: - family-names: Gasparyan given-names: Samvel B. email: gasparyan.co@gmail.com orcid: https://orcid.org/0000-0002-4797-2208 repository: https://samve.r-universe.dev repository-code: https://github.com/Samve/hce commit: 67ad36ca18dddb7a957c11d60e0fa83bf9d9eb47 url: https://github.com/Samve/hce date-released: '2026-05-12' contact: - family-names: Gasparyan given-names: Samvel B. email: gasparyan.co@gmail.com orcid: https://orcid.org/0000-0002-4797-2208