{ "_id": "6a102ec5acfb0bcc41c94734", "Type": "Package", "Package": "hce", "Title": "Design and Analysis of Hierarchical Composite Endpoints", "Version": "0.9.3", "Authors@R": "person(\"Samvel B.\", \"Gasparyan\", , \"gasparyan.co@gmail.com\", role = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0002-4797-2208\"))", "Description": "Simulate and analyze hierarchical composite endpoints.\nIncludes implementation for the kidney hierarchical composite\nendpoint as defined in Heerspink HL et al (2023) “Development\nand validation of a new hierarchical composite end point for\nclinical trials of kidney disease progression” (Journal of the\nAmerican Society of Nephrology 34 (2): 2025–2038,\n). Win odds, also called\nWilcoxon-Mann-Whitney or success odds, is the main analysis\nmethod. Other win statistics (win probability, win ratio, net\nbenefit) are also implemented in the univariate case, provided\nthere is no censoring. The win probability analysis is based on\nthe Brunner-Munzel test and uses the\nDeLong-DeLong-Clarke-Pearson variance estimator, as described\nby Brunner and Konietschke (2025) in “An unbiased rank-based\nestimator of the Mann–Whitney variance including the case of\nties” (Statistical Papers 66 (1): 20,\n). Includes implementation of a\nnew Wilson-type, compatible confidence interval for the win\nodds, as proposed by Schüürhuis, Konietschke, Brunner (2025) in\n“A new approach to the nonparametric Behrens–Fisher problem\nwith compatible confidence intervals.” (Biometrical Journal 67\n(6), ). Stratification and covariate\nadjustment are performed based on the methodology presented by\nKoch GG et al. in “Issues for covariance analysis of\ndichotomous and ordered categorical data from randomized\nclinical trials and non-parametric strategies for addressing\nthem” (Statistics in Medicine 17 (15-16): 1863–92). For a\nreview, see Gasparyan SB et al (2021) “Adjusted win ratio with\nstratification: Calculation methods and interpretation”\n(Statistical Methods in Medical Research 30 (2): 580–611,\n).", "License": "MIT + file LICENSE", "BugReports": "https://github.com/Samve/hce/issues", "Config/testthat/edition": "3", "Encoding": "UTF-8", "LazyData": "true", "Roxygen": "list(markdown = TRUE)", "VignetteBuilder": "knitr", "Config/roxygen2/version": "8.0.0", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-12 19:57:02 UTC", "User": "root" }, "Author": "Samvel B. Gasparyan [aut, cre] (ORCID:\n)", "Maintainer": "Samvel B. 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